Products & Services
SIMABS is a one stop shop with a lean and customer oriented project management approach.
We offer additional services like:
Cell line development
SIMABS has a proprietary cell line technology for recombinant protein production based on CHO cells in a continuous perfusion system. For this stable cell lines are developed as Research Cell Banks but also transient expression for preclinical programs can be performed inhouse. Master Cell Bank generation is outsourced to a third party service provider.
Process Development
Continuous manufacturing is our core business. SIMABS develops cell culture and purification processes specifically into a continuous system. Main advantages of continuous manufacturing are:
- Speed
- Cost effectiveness
- Consistent quality
- Flexibility in amounts from milligrams to kilograms
Our platform is also developed to enable purification of complex mixtures like e.g. bispecific antibodies for immunotherapy.
Analytical & Formulation development
For your analytical development we work together with third party service providers which can cover the range of assays and techniques:
- Protein primary structure (Sequencing, Peptide mapping, Amino acid analysis)
- Glycan analysis (Oligosaccharides, Sialic acid, Monosaccharides)
- Electrophoresis (Gel, capillary)
- Potency assays
- Mass spectrometry
- Biophysical characterisation
- HPLC/UPLC
- Process residuals
- Particulate analysis
SIMABS takes care of the project management of the assay development lifecycle and CMC.
Additional Services
SIMABS provides additional services always with a lean and customer oriented approach. This services may include:
- Quality Management
- Validation
- Project Management
- Technology Transfer to GMP
- Regulatory Affairs
- Clinical Research